Shogun will now face Ovince St. Preux in the featured bout on the Nov. 8 card, which takes place at the Ginásio Municipal Tancredo Neves in Uberlândia, Brazil.
Details on how Manuwa sustained the injury were not revealed.
Rua (22-9) comes into the Fight Night card looking to get back on the winning track after a brutal loss to Dan Henderson last March. In the fight, Rua looked ahead on the scorecards, but Henderson then landed a massive right hand that sent Shogun falling to the canvas. The former UFC light heavyweight champion has lost three of his las four.
St-Preux (16-6) is also coming off a loss, but has had the better run in the UFC, going 4-1 during his Octagon tenure. He was originally tabbed to face Francimar Barroso, and plans to provide Barroso with a replacement opponent were not revealed.
(Image via Dana White’s Instagram)