In addition, featherweights Matt Grice and Dennis Bermudez have also agreed to face off on the UFC 157 card.
UFC officials confirmed the two new bouts on Thursday.
Both Chad Mendes and Manny Gamburyan are looking to get back into the featherweight title hunt as they meet in February.
Mendes lost to champion Jose Aldo to kick off 2012, but came firing back in emphatic fashion with two knockout victories to close out the year. Now he faces Gamburyan with hopes of taking another step towards earning a rematch with Aldo at some point in the future.
Also on the card, Matt Grice looks to build on his last win over Leonard Garcia when he faces former Ultimate Fighter finalist Dennis Bermudez, who currently rides a two fight win streak of his own into the show.
The UFC has not yet announced the placement for either bout on the UFC 157 card.