The UFC made the fight official on Tuesday.
The bout between Dos Santos and Overeem had already been rumored by UFC owner Lorenzo Fertitta earlier this year, but the confirmation on Tuesday means that fight contracts are in place and the fight will happen in May.
Junior Dos Santos claimed the UFC heavyweight title with a rousing victory over former champion Cain Velasquez in November last year at the first ever UFC on Fox event.
Dos Santos crushed Velasquez with a big overhand punch, putting the former Arizona State wrestler down and out early in the first round.
Now Dos Santos will face a fighter with equally deadly stand-up and he has the credentials to prove it.
Alistair Overeem finally made his long awaited UFC debut last December as he put away former champion Brock Lesnar to claim the top spot in the heavyweight contender’s race.
A former K-1 Grand Prix champion, Overeem is as dangerous on his feet as any fighter in the sport today, and he’ll look to add another knockout and title to his list of accolades in May.
Tickets will go on sale for UFC 146: Dos Santos vs. Overeem later in March.