Brown (19-12) is ranked No. 5 in the 170-pound division. He made a run at a title shot by putting together seven-consecutive wins before losing to Robbie Lawler at UFC on FOX 12 in July in a title eliminator bout.
Saffiedine (15-4) is the No. 9-ranked UFC welterweight. He had a five-fight winning streak snapped in his last outing by Rory MacDonald at UFC Fight Night 54 on Oct. 4.
Both fighters are known for their striking ability and aggressive styles.
UFC Fight Night: Brown vs. Saffiedine takes place at the 1stBank Center in Broomfield, Colo., on Feb. 14. It will be the third time the UFC has hosted an event at the 1stBank Center.