UFC officials announced the latest bout on Thursday.
Both men are trying to work their way into title content for the belt currently wrapped around TJ Dillashaw’s waist.
Alcantara (30-5) enters the fight having won back-to-back bouts in his last two outings. His victories over Wilson Reis and Vaughan Lee represent a strong rebound after a disappointing unanimous-decision loss to Urijah Faber last year.
Doane (14-3) is currently on a three-fight winning streak, including his first two UFC bouts. He debuted in the Octagon by defeating Leandro Issa and followed that with a narrow victory over Marcus Brimage.
The two meet in a support bout for the UFC Fight Night 51 headliner between heavyweight Antonio “Bigfoot” Silva and former UFC heavyweight champion Andrei Arlovski.