UFC officials announced the bout on Friday.
Pague (11-8) is likely fighting for his roster spot. He has lost his three most recent bouts and four of his five under the UFC banner.
Pague enters this fight having lost a split decision to Yves Jabouin at UFC 161 in June.
By contrast, Horiguchi (11-1) enters the bout on a five-fight winning streak. This is his UFC debut and has fought the entirety of his career thus far in Japan.
He is the Shooto 132-pound champion, having won the belt earlier this year and defended it once before signing with the UFC.